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  6. CD16 Mouse, anti-Human, FITC, Clone: 3G8, STEMCELL Technologies

CD16 Mouse, anti-Human, FITC, Clone: 3G8, STEMCELL Technologies

Mouse Monoclonal Antibody

193.05€ - 433.35€

Specifications

Antigen CD16
Clone 3G8
Applications Immunohistochemistry, ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence
Classification Monoclonal
Conjugate FITC
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
17108741
Encompass_Preferred
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Stemcell Technologies
60041FI.1 		25 Tests
193.05€
25 tests
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17198731
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Stemcell Technologies
60041FI 		100 Tests
433.35€
100 tests
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Description

Description

  • The 3G8 antibody reacts with CD16 (FcγRIII or low affinity IgG receptor III), a type 1 transmembrane glycoprotein belonging to the Ig superfamily
  • CD16 exists in two distinct isoforms: CD16a, a 50 - 65 kDa form expressed on NK cells, activated monocytes, macrophages, and placental trophoblasts, and CD16b, an ∼48 kDa glycosylphosphatidylinositol (GPI)-anchored form expressed on neutrophils, basophils and eosinophils and found as at least two polymorphic variants, termed NA1 and NA2
  • CD16 binds weakly to the Fc region of monomeric, aggregated or complexed IgG, particularly the IgG1 and IgG3 isotypes
  • Binding of IgG to either CD16 isoform induces signaling pathways that modulate several types of responses, including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, cytokine release and proliferation
  • CD16/IgG interactions can result in non-specific labeling in antibody-based detection and cell separation experiments
Specifications

Specifications

CD16
Immunohistochemistry, ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence
FITC
Baboon, Cynomolgus, Chimpanzee, Human
Primary
3G8
Monoclonal
Mouse
IgG1 κ
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