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  6. CD207 (Langerin) Monoclonal Antibody (eBioL31), eBioscience™, Invitrogen™
  7. 17170602

CD207 (Langerin) Monoclonal Antibody (eBioL31), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-2075-95

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Product Code. 17170602

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Description

Description

The eBioL31 MAb reacts with mouse CD207, also known as Langerin, which is expressed in a distinct subset of dendritic cells called Langerhans cells (LC). Mouse CD207 is a 48 kDa C-type lectin transmembrane protein that likely plays a role in antigen recognition and uptake. LC are located in the epidermis and upon activation, reduce CD207 expression and begin migrating through the dermis towards lymphatic vessels. Expression of mouse CD207 in LC has been correlated to the presence of Birbeck Granules. Furthermore, the formation of Birbeck Granules has been observed upon transfection of CD207 cDNA into fibroblast cell lines. Western Blotting with eBioL31 reveals a 48kDa band in lysate from mouse ear epidermis, as well as in lysates from cells transfected with mouse CD207 cDNA. Preliminary data from mouse CD207 cDNA transfected cells suggests that eBioL31 can be used for intracellular flow cytometric analysis in combination with the Foxp3/Transcription Factor Staining Bufer Set (cat. 00-5523). The epitope recognized by eBioL31 is in the extracellular domain within the CRD (carbohydrate recognition domain) and therefore can be used to detect both surface and intracellular langerin. Differences in expression has been observed between mouse strains.

CD207 (Langerin) Monoclonal antibody specifically detects CD207 (Langerin) in Mouse samples. It is validated for Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD207 (Langerin)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q8VBX4
Rat
10 mg
Primary
Mouse
Antibody
IgG2a
Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
eBioL31
Unconjugated
CD207
CD 207 antigen; Cd207; CD207 antigen; CD207 antigen, langerin; CD207 molecule; CD207 molecule, langerin; Clec4k; C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; Langerhans cell specific c-type lectin; langerin; RGD1565913
Affinity chromatography
RUO
246278
4° C
Liquid
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