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Invitrogen™ CD42b Polyclonal Antibody
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Product Code. 17177213
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Quantity:
100 μL
Unit Size:
100µL
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17177213 100 μL 100µL
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Product Code. 17177213 Supplier Invitrogen™ Supplier No. PA5109282

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Description

Rabbit Polyclonal Antibody

Positive Control: Jurkat, human spleen tissue.

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD42b
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Gp1ba
Gene Accession No. P07359
Gene Alias Antigen CD42b-alpha; BDPLT1; BDPLT3; BSS; CD42a; CD42B; CD42b-alpha; DBPLT3; Glycocalicin; glycoprotein 1b, alpha polypeptide; glycoprotein Ib (platelet), alpha polypeptide; glycoprotein Ib platelet alpha subunit; glycoprotein Ib platelet subunit alpha; glycoprotein Ibalpha; GP1B; GP1BA; GPIB; GPIb alpha; GP-Ib alpha; GPIbA; GPIbalpha; GPIX; GP-IX; MGC34595; mutant platelet membrane glycoprotein Ib-alpha; platelet glycoprotein Ib alpha chain; platelet glycoprotein Ib alpha polypeptide; Platelet GPIX; platelet membrane glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha; VWDP
Gene Symbols Gp1ba
Host Species Rabbit
Immunogen Recombinant protein within Human CD42b aa 117-328.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2811
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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