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CD8a Rat, anti-Mouse, Biotin, Clone: 53-6.7, STEMCELL Technologies
Rat Monoclonal Antibody
Brand: Stemcell Technologies 60023BT.1
This item is not returnable.
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Description
- The 53-6.7 antibody reacts with murine CD8a, a 32 - 34 kDa type I transmembrane glycoprotein which is a subunit of CD8
- CD8 is a disulfide-bonded dimer, found either as a heterodimer of CD8a (α) and CD8b (β) subunits (i.e., αβ) or a homodimer (αα)
- CD8 acts as a co-receptor to the T cell receptor (TCR) during T cell activation by binding MHC Class I molecules presented by an antigen-presenting cell
- It functions to strengthen the association between the TCR and MHC I-antigen complex and to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck
- The CD8a chain binds to the alpha-3 domain of class I MHC molecules
- This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse CD8+ T Cell Isolation Kit (Catalog #19853) and EasySep™ Mouse CD90.2 Positive Selection Kit II (Catalog #18951)
Specifications
| CD8a | |
| Monoclonal | |
| Biotin | |
| 50 μg | |
| Mouse, Frog | |
| T Cells, T Cells, CD8+ |
| CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay | |
| 53-6.7 | |
| Rat | |
| Primary | |
| IgG2a κ |
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