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Invitrogen™ CPI-17 Polyclonal Antibody
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Product Code. 16350545
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Quantity:
100 μL
Unit Size:
100µL
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16350545 100 μL 100µL
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Product Code. 16350545 Supplier Invitrogen™ Supplier No. PA583590

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VKYDRRELQR RLDVEKWIDG RLEELYRGME ADMPDEINID ELLELESEEE RSR Highest antigen sequence indentity to the following orthologs: Mouse - 89%, Rat - 92%.

CPI-17 is a phosphorylation-dependent inhibitory protein for smooth muscle myosin phosphate. CPI-17 was originally identified as a PKC-potentiated inhibitory protein of protein phosphatase-1, which is dominantly expressed in smooth muscle. Phosphorylation at Threonine 38, in vitro, by PKC or Rho-kinase enhances the inhibitory potency toward myosin phosphatase. CPI-17 is also phosphorylated at Threonine 38 by protein kinase N and might be involved in the calcium sensitization of smooth muscle contraction as a downstream effector of Rho and/or arachidonic acid. CPI-17 is dually phosphorylated at Serine 12 and Threonine 38 by a MYPT-associated kinase, M110 kinase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CPI-17
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PPP1R14A
Gene Accession No. Q96A00
Gene Alias 1110001M11Rik; 17 kDa PKC-potentiated inhibitory protein of PP1; 17-kDa PKC-potentiated inhibitory protein of PP1; 17-KDa protein; Cpi; CPI17; CPI-17; PKC-potentiated inhibitory protein of PP1; PPP1INL; PPP1R14A; Protein kinase C-potentiated inhibitor protein of 17 kDa; protein phosphatase 1 regulatory inhibitor subunit 14A; protein phosphatase 1 regulatory subunit 14A; protein phosphatase 1, regulatory (inhibitor) subunit 14A
Gene Symbols PPP1R14A
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PPP1R14A. Recombinant protein control fragment (Product #RP-102920).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 94274
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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