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Invitrogen™ EDG6 Polyclonal Antibody
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Product Code. 17199533
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Quantity:
100 μL
Unit Size:
100µL
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17199533 100 μL 100µL
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Product Code. 17199533 Supplier Invitrogen™ Supplier No. PA5111621

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RSREVCRAVL SFLCCGCLRL GMRGPGDCLA RAVEAHSGAS TTDSSLRPRD S Highest antigen sequence indentity to the following orthologs: Mouse - 86%, Rat - 86%.

EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG6 (S1P4) receptor is the sphingosine 1-phosphate receptor-4 (S1P4).
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Specifications

Antigen EDG6
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene S1PR4
Gene Accession No. O95977
Gene Alias Edg6; EDG-6; Endothelial differentiation G-protein coupled receptor 6; endothelial differentiation G-protein-coupled receptor 6; endothelial differentiation, G protein coupled receptor 6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6; LPC1; Lysophospholipid receptor C1; S1P receptor 4; S1P receptor Edg-6; S1P(4) receptor; S1p4; S1PR4; SLP4; sphingosine 1-phosphate receptor 4; Sphingosine 1-phosphate receptor Edg-6; sphingosine-1-phosphate receptor 4
Gene Symbols S1PR4
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human EDG6. Recombinant protein control fragment (Product #RP-105421).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8698
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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