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Invitrogen™ FOXC1/FOXC2 Polyclonal Antibody
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Product Code. 15587591
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Quantity:
100 μL
Unit Size:
100µL
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15587591 100 μL 100µL
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Product Code. 15587591 Supplier Invitrogen™ Supplier No. PA536261

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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 57 kDa. Purity is >95% by SDS-PAGE.

The forkhead transcription factor genes FOXC1 (Mf1) and FOXC2 (Mfh1) interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop. The genes have similar, dose-dependent functions, and compensate for each other in the early development of the heart, blood vessels and somites. Both FOXC1 and FOXC2 are expressed in the mesenchyme from which the ocular drainage structures derive. FOXC1 and FOXC2 also interact in kidney and heart development. Mutations in the FOXC1 gene result in Axenfeld-Rieger malformations of the anterior segment of the eye and lead to an increased susceptibility of glaucoma, including juvenile glaucoma. Functional regions in FOXC1 are required for nuclear localization and transcriptional regulation. Specifically, two regions in the FOXC1 forkhead domain, one rich in basic amino acid residues, and a second, highly conserved among all FOX proteins, are necessary for nuclear localization of the FOXC1 protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FOXC1/FOXC2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene FOXC1
Gene Accession No. Q12948, Q61572, Q61850, Q63246, Q99958
Gene Alias ARA; BF-3; Brain factor 3; ch; congenital hydrocephalus; Fkh1; fkh-1; Fkh14; FKHL14; FKHL7; forkhead box C1; forkhead box C1 protein; forkhead box C2; forkhead box C2 (MFH-1 mesenchyme forkhead 1); forkhead box C2 (MFH-1, mesenchyme forkhead 1); forkhead box protein C1; Forkhead box protein C2; forkhead homolog 14; forkhead, Drosophila, homolog-like 14; forkhead, drosophila, homolog-like 7; forkhead/winged helix-like transcription factor 7; forkhead-related activator 3; forkhead-related protein FKHL14; Forkhead-related protein FKHL7; forkhead-related transcription factor 3; Foxc1; Foxc2; FREAC3; FREAC-3; frkhda; Hfhbf3; HFH-BF-3; IGDA; IHG1; IRID1; LD; mesenchyme fork head protein 1; mesenchyme forkhead 1; mesoderm/mesenchyme forkhead 1; Mf1; MF-1; Mf4; MFH1; MFH-1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; myeloid factor-delta; RIEG3; Transcription factor FKH-1; transcription factor FKH-14
Gene Symbols FOXC1, FOXC2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 100-150 of human FoxC1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14234, 171356, 17300, 2296, 2303, 364706
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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