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Invitrogen™ Kinesin 5B Monoclonal Antibody (KN-02)
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Product Code. 11524622
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Quantity:
100 μg
Unit Size:
100µg
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11524622 100 μg 100µg
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Product Code. 11524622 Supplier Invitrogen™ Supplier No. MA119352

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Description

Mouse Monoclonal Antibody

This antibody recognizes heavy chain of conventional kinesin, a protein associated with intracellular vesicles, and with lower affinity with denaturated molecule. Epitope is located in coiled-coil stalk domain. It stains Western blots of kinesin-enriched preparations. Epitope mapping (by limited proteolysis of partially purified porcine kinesin) followed by immunoblotting has revealed that antibodies KN-01, KN-02 and KN-03 react with different sets of fragments. The antibody KN-02 does not react with kinesin bound to taxol-stabilized microtubules.

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kinesin 5B
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Monoclonal
Clone KN-02
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 15mM sodium azide; pH 8
Gene KIF5B
Gene Accession No. P33176, Q2PQA9, Q61768
Gene Alias AL022807; Conventional kinesin heavy chain; EMBL:ABC25059.1}; epididymis secretory protein Li 61; HEL-S-61; Khc; Khcs; KIF5A; KIF5B; kif5b {ECO:0000312; kinesin 1 (110-120kD); kinesin family member 5A; kinesin family member 5B; kinesin heavy chain; kinesin heavy chain member 5B, ubiquitous; kinesin-1 heavy chain; KINH; KNS; Kns1; ubiquitous kinesin heavy chain; UKHC; U-KHC; Unknown (protein for IMAGE:7944745)
Gene Symbols KIF5B
Host Species Mouse
Immunogen Enriched fraction of porcine brain kinesin.
Purification Method Sequential chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117550, 16573, 3799, 595132
Target Species Human, Mouse, Rat, Pig
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgM
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