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Invitrogen™ KLF10 Polyclonal Antibody
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Product Code. 11307773
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Quantity:
100 μg
Unit Size:
100µg
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11307773 100 μg 100µg
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Product Code. 11307773 Supplier Invitrogen™ Supplier No. PA519845

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Description

Rabbit Polyclonal Antibody

For Western Blot, this antibody has non-specific bands at 85 kDa. This antibody is predicted to react with cow based on sequence homology.

KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth. It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta thus playing a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth. KLF10 is involved in inducing and promoting apoptosis through the mitochondrial apoptotic pathway and may inhibit Smad7 expression in bronchial epithelial cells. Ubiquitous expression of KLF10 is seen in most of the tissues. Reports suggest that it may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers. Over expression of KLF10 may be associated with renal clear cell carcinoma and other tumors. KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KLF10
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide; pH 7.4
Gene KLF10
Gene Accession No. O08876, O89091, Q13118
Gene Alias AI115143; Cpg20; early growth response-alpha; EGR[a]; EGRA; Egral; EGR-alpha; Gdnfif; GDNF-inducible factor; Klf10; Krueppel-like factor 10; Kruppel like factor 10; Kruppel-like factor 10; mGIF; TGFB inducible early growth response; TGFB inducible early growth response 1; TGFB-inducible early growth response protein 1; Tieg; TIEG1; TIEG-1; transcription factor GIF; Transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor homolog CPG20; zinc finger transcription factor TIEG
Gene Symbols KLF10
Host Species Rabbit
Immunogen Synthetic peptide conjugated to KLH derived from within residues 450 to the C-terminus of Human KLF10.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21847, 7071, 81813
Target Species Human, Mouse, Rat
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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