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Invitrogen™ NAM8 Polyclonal Antibody

Description
NAM8 Polyclonal Antibody for Western Blot, ELISA
Component of the U1 small nuclear ribonucleoprotein complex (U1 snRNP) involved in the initiation of meiotic recombination (PubMed:1603056, PubMed:7625279). Involved in the formation of DSBs at recombination hot-spots through meiosis-specific splicing of REC107 pre-mRNA (PubMed:7625279, PubMed:9112441, PubMed:21788335). Collaborates with MER1 to promote splicing of essential meiotic mRNAs REC10, AMA1, MER3, HFM1, SPO22 and PCH2 (PubMed:10983980, PubMed:21208980, PubMed:21788335). NAM8 interacts with the pre-mRNA downstream of the 5' splice site, in a region of non-conserved sequence and is required for efficient splicing of uncapped RNA precursor (PubMed:10072385).
Specifications
Specifications
| Antigen | NAM8 |
| Applications | ELISA, Western Blot |
| Classification | Polyclonal |
| Concentration | 3.28 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4 |
| Gene | NAM8 |
| Gene Accession No. | Q00539 |
| Gene Alias | MRE2; MUD15 |
| Gene Symbols | NAM8 |
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