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NF2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 10659-1-AP-20UL
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Description
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintece of cell polarity and separation of the lens vesicle from the corneal epithelium.Specifications
| NF2 | |
| Polyclonal | |
| Unconjugated | |
| NF2 | |
| ACN, BANF, Neurofibromin 2, neurofibromin 2 (merlin), NF2, SCH, Schwannomerlin, Schwannomin | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 18016, 25744, 4771 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 0.25 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| P35240, P46662, Q63648 | |
| Nf2 | |
| NF2 Fusion Protein Ag1013 | |
| 20 μL | |
| Primary | |
| Rat, Mouse, Human | |
| Antibody | |
| IgG |
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