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  6. Invitrogen™ Phospho-Ask1 (Thr838) Recombinant Rabbit Monoclonal Antibody (Ask1T838-8D12), Invitrogen™

Invitrogen™ Phospho-Ask1 (Thr838) Recombinant Rabbit Monoclonal Antibody (Ask1T838-8D12), Invitrogen™

Product Code. 17197018 Shop All Thermo Scientific Products
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20 μL
200 μL
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200µL
20µL
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17197018 20 μL 20µL
17116778 200 μL 200µL
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Product Code. 17197018 Supplier Invitrogen™ Supplier No. MA537433

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Description

Rabbit Recombinant Monoclonal Antibody

MAP3K5 (ASK1) is a serine/threonine kinase that is abundantly expressed in human heart and pancreas and are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Ask1 (Thr838)
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone Ask1T838-8D12
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
Gene MAP3K5
Gene Accession No. O35099, Q99683
Gene Alias 7420452D20Rik; apoptosis signal regulating kinase 1; apoptosis signal-regulating kinase 1; ASK; ASK 1; ASK1; ASK-1; EC 2.7.11.25; kinase ASK1; M3K5; MAP/ERK kinase kinase 5; Map3k5; MAPK/ERK kinase kinase 5; MAPKKK5; MEK kinase 5; MEKK 5; Mekk5; mitogen activated protein kinase kinase kinase 5; mitogen-activated protein kinase kinase kinase 5; RGD1306565; RP3-325F22.4
Gene Symbols MAP3K5
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Thr838 of human phospho Ask1.
Purification Method Protein A/G
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26408, 4217
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG κ
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