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Invitrogen™ PR3 Monoclonal Antibody (PR3G-2)
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Product Code. 11529722
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Quantity:
100 μg
Unit Size:
100µg
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11529722 100 μg 100µg
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Product Code. 11529722 Supplier Invitrogen™ Supplier No. MA140218

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770.10 EUR valid until 2026-07-03
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Description

Mouse Monoclonal Antibody

MA1-40218 detects Proteinase 3 from human samples. MA1-40218 has been successfully used in ELISA, flow cytometry, immunohistochemistry (frozen), and Western blot applications. The MA1-40218 immunogen is human PR3. Endotoxin <24 EU/mg.

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen PR3
Applications ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone PR3G-2
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and no preservative
Gene PRTN3
Gene Accession No. P24158
Gene Alias ACPA; AGP7; azurophil granule protein 7; CANCA; C-ANCA; C-ANCA antigen; leukocyte proteinase 3; MBN; MBT; mPR3; Myeloblastin; neutrophil proteinase 4; NP4; NP-4; P29; PR3; PR-3; Proteinase 3; PRTN3; serine proteinase, neutrophil; wegener autoantigen; Wegener granulomatosis autoantigen
Gene Symbols PRTN3
Host Species Mouse
Immunogen Crude alpha granule extract.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5657
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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