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Invitrogen™ PYGO2 Polyclonal Antibody
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Product Code. 17218593 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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17218593 100 μL 100µL
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Product Code. 17218593 Supplier Invitrogen™ Supplier No. PA5115809

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PYGO2.

The PYGO2 gene encodes pygopus family PHD finger 2, a key component of the Wnt signaling pathway, which is critical for embryonic development, cell proliferation, and differentiation. PYGO2 operates as a chromatin remodeling factor, interacting with the beta-catenin-LEF/TCF transcriptional complex, facilitating the transcription of Wnt target genes by recruiting chromatin-modifying enzymes. This activity is vital for maintaining the balance between stem cell renewal and differentiation in various tissues, including the brain and the skin. Additionally, PYGO2 plays significant roles in spermatogenesis and hematopoiesis by modulating gene expression necessary for these processes. Dysregulation of PYGO2 expression can lead to developmental abnormalities and is often implicated in cancer progression, indicating its potential as a biomarker for tumorigenic stem cell-like properties and metastatic behavior. Research continues to explore PYGO2's mechanisms and interactions to understand its contributions to development and its implications in disease states, particularly in cancer biology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PYGO2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene PYGO2
Gene Accession No. Q9BRQ0
Gene Alias 1190004M21Rik; mpygo2; PP7910; PYGO2; pygopus 2; pygopus family PHD finger 2; pygopus homolog 2; RGD1308535
Gene Symbols PYGO2
Host Species Rabbit
Immunogen A synthesized peptide derived from human PYGO2(Accession Q9BRQ0), corresponding to amino acid residues D10-E60.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 90780
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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