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Invitrogen™ Securin Polyclonal Antibody
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Product Code. 17887542
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Quantity:
100 μg
Unit Size:
100µL
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Product Code. Quantity unitSize
17887542 100 μg 100µL
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Product Code. 17887542 Supplier Invitrogen™ Supplier No. PA5142154

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Description

Goat Polyclonal Antibody

Additional Information: Likely to cross-react to PTTG2 and PTTG3. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Securin
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Pttg1
Gene Accession No. O95997
Gene Alias AW555095; C87862; EAP1; Esp1-associated protein; ESP1-associated protein 1; HPTTG; MGC126883; MGC138276; Pituitary tumor transforming; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1; pituitary tumor-transforming gene 1 protein; PTTG; PTTG1; Pttg3; Securin; tumor-transforming protein 1; TUTR1
Gene Symbols Pttg1
Host Species Goat
Immunogen Peptide with sequence C-ILDEERELEKLFQ.
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9232
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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