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Invitrogen™ SnoN Polyclonal Antibody
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Product Code. 16336874
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Quantity:
100 μL
Unit Size:
100µL
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16336874 100 μL 100µL
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Product Code. 16336874 Supplier Invitrogen™ Supplier No. PA578167

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Description

Rabbit Polyclonal Antibody

Positive Control: 293T, A431, HeLa, HepG2, A549, H1299, HCT116, MCF-7, MDA-MB-231 Predicted Reactivity: Mouse (82%), Bovine (88%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SnoN
Applications Western Blot
Classification Polyclonal
Concentration 2.93 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene SKIL
Gene Accession No. P12757
Gene Alias EGK_11909; LOW QUALITY PROTEIN: ski-like protein; SKI like proto-oncogene; ski/sno related; SKIL; SKI-like; SKI-like oncogene; ski-like protein; ski-like protein-like; SKI-like proto-oncogene; Skir; ski-related oncogene; ski-related oncogene snoN; Ski-related protein; SNO; SnoA; SnoI; SnoN; v-ski sarcoma viral oncogene homolog
Gene Symbols SKIL
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human SnoN. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6498
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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