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  6. TNF alpha Mouse anti-Human, Mouse, Clone: 7B8A11, Proteintech

TNF alpha Mouse anti-Human, Mouse, Clone: 7B8A11, Proteintech

Product Code. 16847365 Shop All Proteintech Products
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16847365 20 μL 20µL
16837365 150 μL 150µL
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Product Code. 16847365 Supplier Proteintech Supplier No. 602911IG20UL

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Description

Mouse Monoclonal Antibody

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

Specifications

Antigen TNF alpha
Applications Western Blot, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 7B8A11
Concentration 1.48 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TNF
Gene Accession No. P01375, P06804
Gene Alias Cachectin, DIF, TNF, TNF a, TNF alpha, TNFA, TNF-a, TNFSF2, TNFalpha, Tumor necrosis factor
Gene Symbols TNF
Host Species Mouse
Immunogen TNF alpha Fusion Protein Ag11413
Purification Method Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21926, 7124
Target Species Mouse, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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