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  6. Trimethylacetic anhydride, 99%

Trimethylacetic anhydride, 99%

Product Code. 11496136
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Product Code. 11496136 Supplier Thermo Scientific Alfa Aesar Supplier No. B22983.14
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Description

CAS: 1538-75-6 | C10H18O3 | 186.25 g/mol

Trimethylacetic anhydride is used as acylation and esterification reagents. It is involved in acylation and esterification reactions with anilines and phenols. It is also used in solid-phase oligonucleotide synthesis and in the kinetic resolution of racemic 2-hydroxy-gamma-butyrolactones with diphenylacetic acid. It is also employed in the production of cyano-4, N-tert-butyloxycarbonyl piperidine.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trimethylacetic anhydride is used as acylation and esterification reagents. It is involved in acylation and esterification reactions with anilines and phenols. It is also used in solid-phase oligonucleotide synthesis and in the kinetic resolution of racemic 2-hydroxy-gamma-butyrolactones with diphenylacetic acid. It is also employed in the production of cyano-4, N-tert-butyloxycarbonyl piperidine.

Solubility
Miscible with acetonitrile.

Notes
Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, strong bases and strong reducing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1538-75-6
Molecular Formula C10H18O3
Molecular Weight (g/mol) 186.25
MDL Number MFCD00008842
InChI Key PGZVFRAEAAXREB-UHFFFAOYSA-N
Synonym pivalic anhydride, trimethylacetic anhydride, 2,2-dimethylpropionic anhydride, propanoic acid, 2,2-dimethyl-, anhydride, pivalic anydride, 2,2-dimethylpropanoic anhydride, trimethylacetic acid anhydride, propanoic acid, 2,2-dimethyl-, 1,1'-anhydride, trimethylaceticanhydride, bispivalic anhydride
PubChem CID 15234
IUPAC Name 2,2-dimethylpropanoyl 2,2-dimethylpropanoate
SMILES CC(C)(C)C(=O)OC(=O)C(C)(C)C

Specifications

Density 0.918
Boiling Point 193°C
Flash Point 63°C (145°F)
Odor Unpleasant
Linear Formula ((CH3)3CCO)2O
Refractive Index 1.409
Quantity 25 g
UN Number UN3265
Beilstein 386552
Sensitivity Moisture sensitive
Solubility Information Miscible with acetonitrile.
Formula Weight 186.25
Percent Purity 99%
Chemical Name or Material Trimethylacetic anhydride
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Safety and Handling

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Product Identifier
  • Trimethylacetic anhydride
 Signal Word
  • Danger
 Hazard Category
  • Serious eye damage/eye irritation Category 1
  • Flammable liquid Category 3
  • Skin corrosion/irritation Category 1 B
 Hazard Statement
  • H226-Flammable liquid and vapour.
  • H314-Causes severe skin burns and eye damage.
  • H318-Causes serious eye damage.
 Precautionary Statement
  • P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P310-Immediately call a POISON CENTER/doctor/.
 Supplemental information
  • MIXTURE LIST-Contains : Trimethylacetic anhydride
SDS

RUO – Research Use Only

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