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Invitrogen™ TPH1 Polyclonal Antibody

Product Code. 11509080
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Quantity:
100 μL
Unit Size:
100µL
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11509080 100 μL 100µL
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Product Code. 11509080 Supplier Invitrogen™ Supplier No. PA1777

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Description

Rabbit Polyclonal Antibody

PA1-777 detects TPH1 in human, mouse, rat, rabbit and non-human primate samples. PA1-777 has been successfully used in ICC/IF, IP, and Western blot procedures. By Western blot PA1-777 detects a 51 kDa protein representing TPH1. The PA1-777 immunogen is a synthetic peptide corresponding to the C-terminal region of TPH1.

Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CAM K II) (Jiang et al., 2000; Johansen et al., 1996). Both PKA and CAM K II phosphorylate Ser58 which lies within the regulatory domain of TPH (Kuhn et al., 1997).
TRUSTED_SUSTAINABILITY

Specifications

Antigen TPH1
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene TPH1
Gene Accession No. P09810, P17290, P17532, P17752
Gene Alias indoleacetic acid-5-hydroxylase; L-tryptophan hydroxylase; MGC119994; TPH; Tph1; TPH2; TPRH; TRPH; tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; tryptophan hydroxylase; tryptophan hydroxylase (tryptophan 5-monooxygenase); tryptophan hydroxylase 1; tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)
Gene Symbols TPH1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the C-terminal region of TPH1.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100009100, 100101558, 21990, 24848, 7166
Target Species Human, Mouse, Rat, Rabbit, Monkey
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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