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Invitrogen™ UNC5B Polyclonal Antibody
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Product Code. 17791714
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Quantity:
100 μL
Unit Size:
100µL
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17791714 100 μL 100µL
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Product Code. 17791714 Supplier Invitrogen™ Supplier No. PA5120319

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Description

Rabbit Polyclonal Antibody

Positive test controls include: U-87MG, A-549, 293T, Mouse brain, Mouse lung, Mouse kidney, Rat brain, Rat lung. The target is usually found in the following locations: Cell membrane, Membrane raft, Single-pass type I membrane protein. Immunogen sequence: FQKTACTTIC PVDGAWTEWS KWSACSTECA HWRSRECMAP PPQNGGRDCS GTLLDSKNCT DGLCMQNKKT LSDPNSHLLE ASGDAALY.

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UNC5B
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.985 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene UNC5B
Gene Accession No. O08722, Q8IZJ1, Q8K1S3
Gene Alias 6330415E02Rik; A630020F16; C. elegans; D10Bwg0792e; Netrin receptor UNC5B; p53RDL1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; protein unc-5 homolog B; transmembrane receptor Unc5H2; unc5 homolog 2; unc-5 homolog 2; unc-5 homolog B; unc-5 homolog B (C. elegans); unc-5 netrin receptor B; Unc5b; UNC5H2; UNQ1883/PRO4326
Gene Symbols UNC5B
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 107449, 219699, 60630
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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